Drug interactions
Mycophenolate + Nabumetone
Severity: Moderate
Mycophenolate and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The inactive mycophenolic acid glucuronide metabolite and NSAID metabolites are both cleared by renal tubular secretion, so they may compete for elimination. NSAIDs also add gastrointestinal irritation and renal risk in transplant patients receiving mycophenolate.
What this interaction means in plain words
Mycophenolate and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular secretion of acidic (anionic) compounds and additive gastrointestinal and renal toxicity.
What to do
Monitor renal function and blood counts, and watch for gastrointestinal bleeding or mycophenolate toxicity. Use the lowest effective nabumetone dose for the shortest time, or choose another analgesic such as paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Mycophenolate with Nabumetone?
MediHelp rates the interaction as moderate. Mycophenolate and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The inactive mycophenolic acid glucuronide metabolite and NSAID metabolites are both cleared by renal tubular secretion, so they may compete for elimination. NSAIDs also add gastrointestinal irritation and renal risk in transplant patients receiving mycophenolate.
How serious is the interaction between Mycophenolate and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and blood counts, and watch for gastrointestinal bleeding or mycophenolate toxicity. Use the lowest effective nabumetone dose for the shortest time, or choose another analgesic such as paracetamol.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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