Drug interactions
Mycophenolate + Omeprazole
Severity: Moderate
Mycophenolate and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reduced gastric acidity can lower absorption of mycophenolate mofetil, decreasing mycophenolic acid exposure. This may increase the risk of rejection, but the clinical significance is uncertain. Enteric-coated mycophenolate sodium is less affected.
What this interaction means in plain words
Mycophenolate and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Omeprazole raises gastric pH, reducing dissolution and absorption of mycophenolate mofetil.
What to do
Monitor for graft rejection and consider mycophenolic acid level monitoring. Consider the enteric-coated formulation or reassess PPI need.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Frequently asked questions
Can I take Mycophenolate with Omeprazole?
MediHelp rates the interaction as moderate. Mycophenolate and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Reduced gastric acidity can lower absorption of mycophenolate mofetil, decreasing mycophenolic acid exposure. This may increase the risk of rejection, but the clinical significance is uncertain. Enteric-coated mycophenolate sodium is less affected.
How serious is the interaction between Mycophenolate and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for graft rejection and consider mycophenolic acid level monitoring. Consider the enteric-coated formulation or reassess PPI need.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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