Drug interactions
Mycophenolate + Piroxicam
Severity: Moderate
Mycophenolate and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Piroxicam may raise exposure to the mycophenolic acid glucuronide metabolite and may increase toxicity such as gastrointestinal effects or cytopenias, particularly in renal impairment. NSAIDs can also harm renal function in transplant patients.
What this interaction means in plain words
Mycophenolate and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular secretion of the acidic mycophenolic acid glucuronide, plus NSAID effects on renal function.
What to do
Monitor renal function and blood counts, and watch for gastrointestinal adverse effects. Avoid the NSAID where possible in transplant recipients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Mycophenolate with Piroxicam?
MediHelp rates the interaction as moderate. Mycophenolate and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Piroxicam may raise exposure to the mycophenolic acid glucuronide metabolite and may increase toxicity such as gastrointestinal effects or cytopenias, particularly in renal impairment. NSAIDs can also harm renal function in transplant patients.
How serious is the interaction between Mycophenolate and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and blood counts, and watch for gastrointestinal adverse effects. Avoid the NSAID where possible in transplant recipients.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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