Drug interactions
Mycophenolate + Sirolimus
Severity: Moderate
Mycophenolate and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus and mycophenolate are often given together in transplant regimens, but their immunosuppressive effects add up. Infection risk and myelosuppression (leukopenia, anemia) are increased.
What this interaction means in plain words
Mycophenolate and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression via mTOR inhibition and inosine monophosphate dehydrogenase inhibition.
What to do
Monitor blood counts and signs of infection regularly. Adjust doses by transplant protocol and trough levels, and reduce mycophenolate dose if cytopenias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Mycophenolate with Sirolimus?
MediHelp rates the interaction as moderate. Mycophenolate and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sirolimus and mycophenolate are often given together in transplant regimens, but their immunosuppressive effects add up. Infection risk and myelosuppression (leukopenia, anemia) are increased.
How serious is the interaction between Mycophenolate and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of infection regularly. Adjust doses by transplant protocol and trough levels, and reduce mycophenolate dose if cytopenias develop.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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