Drug interactions
Mycophenolate + Tacrolimus
Severity: Moderate
Mycophenolate and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This is a standard transplant combination, but together the drugs increase overall immunosuppression and the risk of infection and malignancy. Tacrolimus may also modestly raise exposure to mycophenolic acid.
What this interaction means in plain words
Mycophenolate and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression through calcineurin inhibition and inhibition of lymphocyte purine synthesis.
What to do
Use together under transplant-specialist protocols with tacrolimus trough monitoring. Monitor blood counts and watch for infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Mycophenolate with Tacrolimus?
MediHelp rates the interaction as moderate. Mycophenolate and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This is a standard transplant combination, but together the drugs increase overall immunosuppression and the risk of infection and malignancy. Tacrolimus may also modestly raise exposure to mycophenolic acid.
How serious is the interaction between Mycophenolate and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together under transplant-specialist protocols with tacrolimus trough monitoring. Monitor blood counts and watch for infection.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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