Drug interactions
Mycophenolate mofetil + Pneumococcal vaccine heptavalent
Severity: Moderate
Mycophenolate mofetil and Pneumococcal vaccine heptavalent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mycophenolate may reduce the antibody response to pneumococcal conjugate vaccine. The vaccine is non-live and is recommended for immunosuppressed patients despite the reduced response.
What this interaction means in plain words
Mycophenolate mofetil and Pneumococcal vaccine heptavalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Impaired lymphocyte proliferation lowers vaccine-induced antibody production.
What to do
Vaccinate according to immunocompromised schedules and ideally before starting mycophenolate. Do not withhold the vaccine because of the reduced response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Frequently asked questions
Can I take Mycophenolate mofetil with Pneumococcal vaccine heptavalent?
MediHelp rates the interaction as moderate. Mycophenolate mofetil and Pneumococcal vaccine heptavalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mycophenolate may reduce the antibody response to pneumococcal conjugate vaccine. The vaccine is non-live and is recommended for immunosuppressed patients despite the reduced response.
How serious is the interaction between Mycophenolate mofetil and Pneumococcal vaccine heptavalent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate according to immunocompromised schedules and ideally before starting mycophenolate. Do not withhold the vaccine because of the reduced response.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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