Drug interactions
Mycophenolate mofetil + Pneumococcal vaccine polyvalent
Severity: Moderate
Mycophenolate mofetil and Pneumococcal vaccine polyvalent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibody responses to polysaccharide pneumococcal vaccine can be lower in patients on mycophenolate. Protection against invasive disease may be incomplete.
What this interaction means in plain words
Mycophenolate mofetil and Pneumococcal vaccine polyvalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
IMPDH inhibition restricts B and T lymphocyte proliferation, reducing vaccine response.
What to do
Follow immunocompromised schedules and give the vaccine before immunosuppression if possible. Review revaccination timing according to local guidelines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Frequently asked questions
Can I take Mycophenolate mofetil with Pneumococcal vaccine polyvalent?
MediHelp rates the interaction as moderate. Mycophenolate mofetil and Pneumococcal vaccine polyvalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antibody responses to polysaccharide pneumococcal vaccine can be lower in patients on mycophenolate. Protection against invasive disease may be incomplete.
How serious is the interaction between Mycophenolate mofetil and Pneumococcal vaccine polyvalent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow immunocompromised schedules and give the vaccine before immunosuppression if possible. Review revaccination timing according to local guidelines.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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