Drug interactions
Mycophenolate mofetil + Polysaccharide iron
Severity: Moderate
Mycophenolate mofetil and Polysaccharide iron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral iron given at the same time as mycophenolate may reduce absorption of mycophenolic acid in some reports, though other studies show no meaningful effect. The clinical impact is generally small but could matter in transplant recipients with borderline exposure.
What this interaction means in plain words
Mycophenolate mofetil and Polysaccharide iron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible binding or chelation of mycophenolate by iron in the gastrointestinal tract, reducing absorption.
What to do
Separate oral iron and mycophenolate administration by at least 2 hours and monitor for loss of immunosuppressive efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mycophenolate mofetil and Polysaccharide iron, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Frequently asked questions
Can I take Mycophenolate mofetil with Polysaccharide iron?
MediHelp rates the interaction as moderate. Mycophenolate mofetil and Polysaccharide iron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral iron given at the same time as mycophenolate may reduce absorption of mycophenolic acid in some reports, though other studies show no meaningful effect. The clinical impact is generally small but could matter in transplant recipients with borderline exposure.
How serious is the interaction between Mycophenolate mofetil and Polysaccharide iron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate oral iron and mycophenolate administration by at least 2 hours and monitor for loss of immunosuppressive efficacy.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
