Drug interactions
Mycophenolate mofetil + Rabeprazole
Severity: Moderate
Mycophenolate mofetil and Rabeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Proton pump inhibitors can reduce the absorption of mycophenolate mofetil and lower mycophenolic acid exposure in some patients. The clinical impact on rejection rates is uncertain, and enteric-coated mycophenolate sodium is less affected.
What this interaction means in plain words
Mycophenolate mofetil and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mycophenolate mofetil belongs to Miscellaneous; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Higher gastric pH reduces dissolution and absorption of mycophenolate mofetil.
What to do
Use a PPI only when indicated and monitor for loss of immunosuppressive effect. Consider mycophenolic acid level monitoring or switching to enteric-coated mycophenolate sodium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Frequently asked questions
Can I take Mycophenolate mofetil with Rabeprazole?
MediHelp rates the interaction as moderate. Mycophenolate mofetil and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Proton pump inhibitors can reduce the absorption of mycophenolate mofetil and lower mycophenolic acid exposure in some patients. The clinical impact on rejection rates is uncertain, and enteric-coated mycophenolate sodium is less affected.
How serious is the interaction between Mycophenolate mofetil and Rabeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a PPI only when indicated and monitor for loss of immunosuppressive effect. Consider mycophenolic acid level monitoring or switching to enteric-coated mycophenolate sodium.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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