Drug interactions
Mycophenolate mofetil + Rabies vaccine
Severity: Major
Mycophenolate mofetil and Rabies vaccine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rabies vaccine is inactivated, but mycophenolate may result in inadequate neutralising antibody levels. Because rabies is almost always fatal, a poor response is clinically important.
What this interaction means in plain words
Mycophenolate mofetil and Rabies vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
IMPDH inhibition suppresses lymphocyte proliferation and weakens vaccine-induced immunity.
What to do
Give rabies vaccine whenever indicated and do not delay post-exposure prophylaxis; add rabies immunoglobulin when indicated. Check neutralising antibody titres after vaccination and give extra doses if inadequate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Frequently asked questions
Can I take Mycophenolate mofetil with Rabies vaccine?
MediHelp rates the interaction as major. Mycophenolate mofetil and Rabies vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rabies vaccine is inactivated, but mycophenolate may result in inadequate neutralising antibody levels. Because rabies is almost always fatal, a poor response is clinically important.
How serious is the interaction between Mycophenolate mofetil and Rabies vaccine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give rabies vaccine whenever indicated and do not delay post-exposure prophylaxis; add rabies immunoglobulin when indicated. Check neutralising antibody titres after vaccination and give extra doses if inadequate.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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