Drug interactions
Mycophenolate mofetil + Salicylates
Severity: Minor
Mycophenolate mofetil and Salicylates: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates are acidic and may displace mycophenolic acid from albumin and compete for renal tubular secretion of its glucuronide. This could modestly raise free drug exposure. Clinical consequences are generally small.
What this interaction means in plain words
Mycophenolate mofetil and Salicylates have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Protein-binding displacement and competition for renal tubular secretion of mycophenolic acid and its glucuronide.
What to do
Monitor blood counts and renal function if used regularly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Frequently asked questions
Can I take Mycophenolate mofetil with Salicylates?
MediHelp rates the interaction as minor. Mycophenolate mofetil and Salicylates have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salicylates are acidic and may displace mycophenolic acid from albumin and compete for renal tubular secretion of its glucuronide. This could modestly raise free drug exposure. Clinical consequences are generally small.
How serious is the interaction between Mycophenolate mofetil and Salicylates?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and renal function if used regularly.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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