Drug interactions
Mycophenolate mofetil + Sulfasalazine
Severity: Moderate
Mycophenolate mofetil and Sulfasalazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine is acidic and may compete with mycophenolic acid glucuronide for renal tubular secretion, possibly raising exposure slightly. Both drugs can also cause leukopenia, so hematologic effects may be additive.
What this interaction means in plain words
Mycophenolate mofetil and Sulfasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible competition for renal tubular secretion plus additive myelosuppressive potential.
What to do
Monitor complete blood counts regularly. Reduce the dose of either drug if cytopenias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Frequently asked questions
Can I take Mycophenolate mofetil with Sulfasalazine?
MediHelp rates the interaction as moderate. Mycophenolate mofetil and Sulfasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfasalazine is acidic and may compete with mycophenolic acid glucuronide for renal tubular secretion, possibly raising exposure slightly. Both drugs can also cause leukopenia, so hematologic effects may be additive.
How serious is the interaction between Mycophenolate mofetil and Sulfasalazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly. Reduce the dose of either drug if cytopenias develop.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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