Drug interactions
Mycophenolate mofetil + Telmisartan
Severity: Moderate
Mycophenolate mofetil and Telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telmisartan may lower mycophenolic acid concentrations, which could reduce immunosuppressive efficacy and raise the risk of rejection. The effect has been described mainly in pharmacokinetic studies, and its clinical consequence is not fully established.
What this interaction means in plain words
Mycophenolate mofetil and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mycophenolate mofetil belongs to Miscellaneous; Telmisartan belongs to Cardiovascular.
Why it happens
Telmisartan may upregulate PPAR-gamma, increasing UGT1A9 expression and enhancing glucuronidation of mycophenolic acid.
What to do
Monitor for signs of reduced immunosuppression and consider measuring mycophenolic acid exposure when starting or stopping telmisartan. Adjust the mycophenolate dose according to levels and clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Frequently asked questions
Can I take Mycophenolate mofetil with Telmisartan?
MediHelp rates the interaction as moderate. Mycophenolate mofetil and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telmisartan may lower mycophenolic acid concentrations, which could reduce immunosuppressive efficacy and raise the risk of rejection. The effect has been described mainly in pharmacokinetic studies, and its clinical consequence is not fully established.
How serious is the interaction between Mycophenolate mofetil and Telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of reduced immunosuppression and consider measuring mycophenolic acid exposure when starting or stopping telmisartan. Adjust the mycophenolate dose according to levels and clinical response.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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