Drug interactions
Mycophenolate mofetil + Tofacitinib
Severity: Major
Mycophenolate mofetil and Tofacitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tofacitinib labeling advises against use with potent immunosuppressants, and mycophenolate falls into this group. Combined use raises the risk of serious infection, lymphoma and other malignancies.
What this interaction means in plain words
Mycophenolate mofetil and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mycophenolate mofetil belongs to Miscellaneous; Tofacitinib belongs to Musculoskeletal.
Why it happens
Additive immunosuppression via JAK inhibition and inhibition of lymphocyte proliferation.
What to do
Avoid concurrent use where possible; if unavoidable, monitor for infection and lymphocyte and neutrophil counts, and stop tofacitinib if a serious infection occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Frequently asked questions
Can I take Mycophenolate mofetil with Tofacitinib?
MediHelp rates the interaction as major. Mycophenolate mofetil and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tofacitinib labeling advises against use with potent immunosuppressants, and mycophenolate falls into this group. Combined use raises the risk of serious infection, lymphoma and other malignancies.
How serious is the interaction between Mycophenolate mofetil and Tofacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; if unavoidable, monitor for infection and lymphocyte and neutrophil counts, and stop tofacitinib if a serious infection occurs.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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