Drug interactions
Mycophenolate mofetil + Typhoid vaccine live
Severity: Contraindicated
Mycophenolate mofetil and Typhoid vaccine live: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral live typhoid vaccine (Ty21a) contains attenuated bacteria that could cause invasive infection in immunosuppressed patients. Mycophenolate also reduces vaccine response.
What this interaction means in plain words
Mycophenolate mofetil and Typhoid vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Impaired immunity permits replication of live attenuated Salmonella Typhi.
What to do
Avoid the live oral vaccine and use the inactivated injectable polysaccharide vaccine instead.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Frequently asked questions
Can I take Mycophenolate mofetil with Typhoid vaccine live?
MediHelp rates the interaction as contraindicated. Mycophenolate mofetil and Typhoid vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oral live typhoid vaccine (Ty21a) contains attenuated bacteria that could cause invasive infection in immunosuppressed patients. Mycophenolate also reduces vaccine response.
How serious is the interaction between Mycophenolate mofetil and Typhoid vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the live oral vaccine and use the inactivated injectable polysaccharide vaccine instead.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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