Drug interactions
Mycophenolate mofetil + Zoster vaccine recombinant
Severity: Minor
Mycophenolate mofetil and Zoster vaccine recombinant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mycophenolate may reduce the immune response to recombinant zoster vaccine. The vaccine is non-live and recommended for immunocompromised adults, so protection may be lower but vaccination remains worthwhile.
What this interaction means in plain words
Mycophenolate mofetil and Zoster vaccine recombinant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic antagonism: suppressed lymphocyte proliferation reduces vaccine antibody and T-cell responses.
What to do
Give the two-dose series as recommended, ideally before intensifying immunosuppression when possible. Do not delay vaccination if immunosuppression is ongoing.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Frequently asked questions
Can I take Mycophenolate mofetil with Zoster vaccine recombinant?
MediHelp rates the interaction as minor. Mycophenolate mofetil and Zoster vaccine recombinant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mycophenolate may reduce the immune response to recombinant zoster vaccine. The vaccine is non-live and recommended for immunocompromised adults, so protection may be lower but vaccination remains worthwhile.
How serious is the interaction between Mycophenolate mofetil and Zoster vaccine recombinant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the two-dose series as recommended, ideally before intensifying immunosuppression when possible. Do not delay vaccination if immunosuppression is ongoing.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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