Drug interactions
Nabilone + Olanzapine
Severity: Moderate
Nabilone and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine is markedly sedating and nabilone adds CNS depression, so drowsiness and dizziness may increase. Both can also cause orthostatic hypotension and tachycardia.
What this interaction means in plain words
Nabilone and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nabilone belongs to Gastrointestinal Tract; Olanzapine belongs to Central Nervous System.
Why it happens
Additive CNS depressant and hypotensive effects.
What to do
Monitor sedation and orthostatic blood pressure, and advise against driving until the response is known. Consider dose reduction if oversedation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Olanzapine
Frequently asked questions
Can I take Nabilone with Olanzapine?
MediHelp rates the interaction as moderate. Nabilone and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine is markedly sedating and nabilone adds CNS depression, so drowsiness and dizziness may increase. Both can also cause orthostatic hypotension and tachycardia.
How serious is the interaction between Nabilone and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and orthostatic blood pressure, and advise against driving until the response is known. Consider dose reduction if oversedation develops.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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