Drug interactions
Nabilone + Olopatadine intranasal
Severity: Moderate
Nabilone and Olopatadine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nabilone commonly causes drowsiness and dizziness, and intranasal olopatadine can cause somnolence. Used together they may increase CNS depression and impair psychomotor performance.
What this interaction means in plain words
Nabilone and Olopatadine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sedation from cannabinoid receptor agonism and antihistaminic effects.
What to do
Advise patients to avoid driving and hazardous activities. Consider a non-sedating alternative to olopatadine if drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Frequently asked questions
Can I take Nabilone with Olopatadine intranasal?
MediHelp rates the interaction as moderate. Nabilone and Olopatadine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nabilone commonly causes drowsiness and dizziness, and intranasal olopatadine can cause somnolence. Used together they may increase CNS depression and impair psychomotor performance.
How serious is the interaction between Nabilone and Olopatadine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving and hazardous activities. Consider a non-sedating alternative to olopatadine if drowsiness occurs.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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