Drug interactions
Nabilone + Orphenadrine
Severity: Moderate
Nabilone and Orphenadrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine is an anticholinergic muscle relaxant that causes drowsiness, dizziness and confusion. Combined with nabilone, sedation and cognitive impairment may increase, and additive anticholinergic effects such as tachycardia can occur.
What this interaction means in plain words
Nabilone and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and additive tachycardia from anticholinergic and cannabinoid effects.
What to do
Monitor for oversedation, confusion and tachycardia, especially in older adults. Reduce doses if impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Frequently asked questions
Can I take Nabilone with Orphenadrine?
MediHelp rates the interaction as moderate. Nabilone and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine is an anticholinergic muscle relaxant that causes drowsiness, dizziness and confusion. Combined with nabilone, sedation and cognitive impairment may increase, and additive anticholinergic effects such as tachycardia can occur.
How serious is the interaction between Nabilone and Orphenadrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, confusion and tachycardia, especially in older adults. Reduce doses if impairment occurs.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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