Drug interactions
Nabilone + Papaveretum
Severity: Major
Nabilone and Papaveretum: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum is an opium alkaloid mixture containing morphine, and it causes sedation and respiratory depression. Nabilone adds CNS depression, so the combination can lead to profound drowsiness and impaired breathing.
What this interaction means in plain words
Nabilone and Papaveretum can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from opioid agonism and cannabinoid activity.
What to do
Use the lowest effective doses and monitor sedation and respiratory rate closely. Avoid unsupervised use in opioid-naive or frail patients.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nabilone
Frequently asked questions
Can I take Nabilone with Papaveretum?
MediHelp rates the interaction as major. Nabilone and Papaveretum can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Papaveretum is an opium alkaloid mixture containing morphine, and it causes sedation and respiratory depression. Nabilone adds CNS depression, so the combination can lead to profound drowsiness and impaired breathing.
How serious is the interaction between Nabilone and Papaveretum?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory rate closely. Avoid unsupervised use in opioid-naive or frail patients.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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