Drug interactions
Nabilone + Phendimetrazine
Severity: Minor
Nabilone and Phendimetrazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phendimetrazine is a sympathomimetic anorectic that can cause tachycardia and hypertension, and nabilone can also increase heart rate. The stimulant is not a dependable reversal of nabilone sedation and the combined cardiovascular effect may be additive.
What this interaction means in plain words
Nabilone and Phendimetrazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive tachycardia from sympathomimetic action and cannabinoid effects; no established pharmacokinetic mechanism.
What to do
Monitor heart rate and blood pressure, and counsel the patient about palpitations and mood changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nabilone
Frequently asked questions
Can I take Nabilone with Phendimetrazine?
MediHelp rates the interaction as minor. Nabilone and Phendimetrazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phendimetrazine is a sympathomimetic anorectic that can cause tachycardia and hypertension, and nabilone can also increase heart rate. The stimulant is not a dependable reversal of nabilone sedation and the combined cardiovascular effect may be additive.
How serious is the interaction between Nabilone and Phendimetrazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, and counsel the patient about palpitations and mood changes.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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