Drug interactions
Nabilone + Phenylephrine
Severity: Moderate
Nabilone and Phenylephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nabilone, a cannabinoid, can cause tachycardia and postural blood pressure changes, and phenylephrine is a sympathomimetic that raises blood pressure. Combined use may produce additive cardiovascular effects such as tachycardia and hypertension.
What this interaction means in plain words
Nabilone and Phenylephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nabilone belongs to Gastrointestinal Tract; Phenylephrine belongs to Respiratory.
Why it happens
Additive pharmacodynamic cardiovascular effects of cannabinoid-induced tachycardia and adrenergic vasoconstriction.
What to do
Monitor heart rate and blood pressure when starting or adjusting either drug. Use caution in patients with cardiovascular disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenylephrine
- Isocarboxazid + Phenylephrine Contraindicated
- Phenelzine + Phenylephrine Contraindicated
- Phenylephrine + Tranylcypromine Contraindicated
- Bromocriptine + Phenylephrine Major
- Cocaine + Phenylephrine Major
- Dihydroergotamine intranasal + Phenylephrine Major
Other interactions of Nabilone
Frequently asked questions
Can I take Nabilone with Phenylephrine?
MediHelp rates the interaction as moderate. Nabilone and Phenylephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nabilone, a cannabinoid, can cause tachycardia and postural blood pressure changes, and phenylephrine is a sympathomimetic that raises blood pressure. Combined use may produce additive cardiovascular effects such as tachycardia and hypertension.
How serious is the interaction between Nabilone and Phenylephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or adjusting either drug. Use caution in patients with cardiovascular disease.
What other medicines interact with Phenylephrine?
MediHelp also lists interactions of Phenylephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Phenylephrine page.
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