Drug interactions
Nabilone + Pholcodine
Severity: Moderate
Nabilone and Pholcodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pholcodine is an opioid cough suppressant with sedative properties, and nabilone adds CNS depression. The combination may increase drowsiness and impair alertness.
What this interaction means in plain words
Nabilone and Pholcodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid and cannabinoid activity.
What to do
Monitor for excessive drowsiness and advise the patient not to drive or use machinery. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nabilone and Pholcodine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Nabilone
Frequently asked questions
Can I take Nabilone with Pholcodine?
MediHelp rates the interaction as moderate. Nabilone and Pholcodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pholcodine is an opioid cough suppressant with sedative properties, and nabilone adds CNS depression. The combination may increase drowsiness and impair alertness.
How serious is the interaction between Nabilone and Pholcodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive drowsiness and advise the patient not to drive or use machinery. Use the lowest effective doses.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
