Drug interactions
Nabilone + Pimozide
Severity: Moderate
Nabilone and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause sedation, so combining them can increase drowsiness and impair alertness and coordination. Pimozide also has cardiac effects, and nabilone-related tachycardia and blood pressure changes may be unwelcome in this setting.
What this interaction means in plain words
Nabilone and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nabilone belongs to Gastrointestinal Tract; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS depression with overlapping cardiovascular effects.
What to do
Monitor sedation, heart rate and blood pressure, and review ECG and electrolytes per usual pimozide monitoring. Advise against driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Nabilone with Pimozide?
MediHelp rates the interaction as moderate. Nabilone and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause sedation, so combining them can increase drowsiness and impair alertness and coordination. Pimozide also has cardiac effects, and nabilone-related tachycardia and blood pressure changes may be unwelcome in this setting.
How serious is the interaction between Nabilone and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, heart rate and blood pressure, and review ECG and electrolytes per usual pimozide monitoring. Advise against driving until the response is known.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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