Drug interactions
Nabilone + Protriptyline
Severity: Moderate
Nabilone and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause tachycardia, and combined use has been associated with additive tachycardia, hypertension and drowsiness. Protriptyline is less sedating than other tricyclics but still has anticholinergic effects that may compound those of nabilone.
What this interaction means in plain words
Nabilone and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive tachycardia, anticholinergic effects and CNS depression from a tricyclic antidepressant and a cannabinoid.
What to do
Monitor heart rate, blood pressure and sedation, especially in patients with cardiovascular disease. Reduce doses or choose an alternative if tachyarrhythmia or marked drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nabilone and Protriptyline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Nabilone
Frequently asked questions
Can I take Nabilone with Protriptyline?
MediHelp rates the interaction as moderate. Nabilone and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause tachycardia, and combined use has been associated with additive tachycardia, hypertension and drowsiness. Protriptyline is less sedating than other tricyclics but still has anticholinergic effects that may compound those of nabilone.
How serious is the interaction between Nabilone and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and sedation, especially in patients with cardiovascular disease. Reduce doses or choose an alternative if tachyarrhythmia or marked drowsiness occurs.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
