Drug interactions
Nabilone + Thiothixene
Severity: Moderate
Nabilone and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nabilone and the antipsychotic thiothixene both cause sedation, so combined use can increase drowsiness and reduce alertness. Nabilone can also cause tachycardia and orthostatic hypotension, which may add to the antipsychotic's effects.
What this interaction means in plain words
Nabilone and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects of a cannabinoid agonist and a sedating dopamine/histamine-blocking antipsychotic.
What to do
Monitor for oversedation and orthostatic hypotension, and titrate doses slowly. Advise patients to avoid driving or operating machinery until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nabilone and Thiothixene, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Nabilone
Frequently asked questions
Can I take Nabilone with Thiothixene?
MediHelp rates the interaction as moderate. Nabilone and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nabilone and the antipsychotic thiothixene both cause sedation, so combined use can increase drowsiness and reduce alertness. Nabilone can also cause tachycardia and orthostatic hypotension, which may add to the antipsychotic's effects.
How serious is the interaction between Nabilone and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and orthostatic hypotension, and titrate doses slowly. Advise patients to avoid driving or operating machinery until the response is known.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
