Drug interactions
Nabilone + Triazolam
Severity: Moderate
Nabilone and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining nabilone with triazolam can increase sedation, impair psychomotor function and worsen memory and coordination. The risk is greatest in older or frail patients and when alcohol is also used.
What this interaction means in plain words
Nabilone and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from cannabinoid receptor agonism and benzodiazepine GABA-A potentiation.
What to do
Use the lowest effective triazolam dose and monitor for excessive sedation or confusion. Counsel against driving and alcohol use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Frequently asked questions
Can I take Nabilone with Triazolam?
MediHelp rates the interaction as moderate. Nabilone and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining nabilone with triazolam can increase sedation, impair psychomotor function and worsen memory and coordination. The risk is greatest in older or frail patients and when alcohol is also used.
How serious is the interaction between Nabilone and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective triazolam dose and monitor for excessive sedation or confusion. Counsel against driving and alcohol use.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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