Drug interactions
Nabilone + Trifluoperazine
Severity: Moderate
Nabilone and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause drowsiness, so together they may increase sedation and impair alertness. Additive orthostatic hypotension and tachycardia are also possible.
What this interaction means in plain words
Nabilone and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant and autonomic effects of a cannabinoid agonist and a phenothiazine antipsychotic.
What to do
Monitor for oversedation and orthostatic blood pressure changes, titrating doses gradually. Advise patients to avoid driving until tolerance is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Frequently asked questions
Can I take Nabilone with Trifluoperazine?
MediHelp rates the interaction as moderate. Nabilone and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause drowsiness, so together they may increase sedation and impair alertness. Additive orthostatic hypotension and tachycardia are also possible.
How serious is the interaction between Nabilone and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and orthostatic blood pressure changes, titrating doses gradually. Advise patients to avoid driving until tolerance is established.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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