Drug interactions
Nabilone + Triprolidine
Severity: Moderate
Nabilone and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triprolidine is a first-generation sedating antihistamine. With nabilone it can produce additive drowsiness, impaired concentration and slowed reaction time.
What this interaction means in plain words
Nabilone and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nabilone belongs to Gastrointestinal Tract; Triprolidine belongs to Respiratory.
Why it happens
Additive CNS depression from H1-receptor antagonism and cannabinoid receptor agonism.
What to do
Advise the patient to avoid driving and hazardous tasks, and consider a non-sedating antihistamine. Monitor for oversedation, especially in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Triprolidine
Frequently asked questions
Can I take Nabilone with Triprolidine?
MediHelp rates the interaction as moderate. Nabilone and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triprolidine is a first-generation sedating antihistamine. With nabilone it can produce additive drowsiness, impaired concentration and slowed reaction time.
How serious is the interaction between Nabilone and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise the patient to avoid driving and hazardous tasks, and consider a non-sedating antihistamine. Monitor for oversedation, especially in older adults.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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