Drug interactions
Nabilone + Yohimbine
Severity: Moderate
Nabilone and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nabilone is sedating while yohimbine is a stimulant, so their effects on alertness may partly oppose each other. Both can raise heart rate, and yohimbine may cause anxiety or hypertension, which can add to nabilone's cardiovascular and psychiatric effects.
What this interaction means in plain words
Nabilone and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing CNS effects, with possible additive tachycardia, from cannabinoid agonism and alpha-2 adrenergic antagonism; the net effect is not well established.
What to do
Monitor heart rate, blood pressure and anxiety or agitation. Do not rely on yohimbine to offset nabilone sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nabilone and Yohimbine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Nabilone
Frequently asked questions
Can I take Nabilone with Yohimbine?
MediHelp rates the interaction as moderate. Nabilone and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nabilone is sedating while yohimbine is a stimulant, so their effects on alertness may partly oppose each other. Both can raise heart rate, and yohimbine may cause anxiety or hypertension, which can add to nabilone's cardiovascular and psychiatric effects.
How serious is the interaction between Nabilone and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and anxiety or agitation. Do not rely on yohimbine to offset nabilone sedation.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
