Drug interactions
Nabumetone + Nefazodone
Severity: Moderate
Nabumetone and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone has serotonergic activity that can impair platelet function, and when combined with an NSAID the risk of gastrointestinal bleeding is increased. The risk is greatest in older patients and those with prior ulcer disease.
What this interaction means in plain words
Nabumetone and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of platelet aggregation (serotonin uptake inhibition plus COX inhibition) together with NSAID-induced gastric mucosal injury.
What to do
Monitor for signs of gastrointestinal bleeding and consider gastroprotection with a proton pump inhibitor in high-risk patients. Use the lowest effective NSAID dose or consider an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nabumetone and Nefazodone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Nabumetone with Nefazodone?
MediHelp rates the interaction as moderate. Nabumetone and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone has serotonergic activity that can impair platelet function, and when combined with an NSAID the risk of gastrointestinal bleeding is increased. The risk is greatest in older patients and those with prior ulcer disease.
How serious is the interaction between Nabumetone and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of gastrointestinal bleeding and consider gastroprotection with a proton pump inhibitor in high-risk patients. Use the lowest effective NSAID dose or consider an alternative analgesic.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
