Drug interactions
Nabumetone + Olmesartan
Severity: Major
Nabumetone and Olmesartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the antihypertensive effect of angiotensin receptor blockers and, together, increase the risk of acute kidney injury and hyperkalemia. Risk is greatest in elderly, volume-depleted or renally impaired patients, especially if a diuretic is also taken.
What this interaction means in plain words
Nabumetone and Olmesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nabumetone belongs to Musculoskeletal; Olmesartan belongs to Cardiovascular.
Why it happens
NSAIDs block prostaglandin-mediated afferent arteriolar dilation while the ARB dilates the efferent arteriole, reducing glomerular filtration and promoting sodium retention and potassium accumulation.
What to do
Avoid the combination where possible, or ensure adequate hydration and monitor serum creatinine, potassium and blood pressure within the first weeks. Stop the NSAID if renal function declines.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Nabumetone with Olmesartan?
MediHelp rates the interaction as major. Nabumetone and Olmesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs can reduce the antihypertensive effect of angiotensin receptor blockers and, together, increase the risk of acute kidney injury and hyperkalemia. Risk is greatest in elderly, volume-depleted or renally impaired patients, especially if a diuretic is also taken.
How serious is the interaction between Nabumetone and Olmesartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or ensure adequate hydration and monitor serum creatinine, potassium and blood pressure within the first weeks. Stop the NSAID if renal function declines.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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