Drug interactions
Nabumetone + Phenindione
Severity: Major
Nabumetone and Phenindione: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenindione is an oral vitamin K antagonist, and nabumetone adds platelet inhibition and risk of gastrointestinal mucosal injury. The combination raises the likelihood of serious bleeding.
What this interaction means in plain words
Nabumetone and Phenindione can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive hemostatic impairment: vitamin K antagonism reducing clotting factor synthesis plus NSAID antiplatelet effect and mucosal damage.
What to do
Avoid the NSAID when possible and use paracetamol instead. If unavoidable, monitor INR closely and consider gastroprotection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Nabumetone with Phenindione?
MediHelp rates the interaction as major. Nabumetone and Phenindione can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenindione is an oral vitamin K antagonist, and nabumetone adds platelet inhibition and risk of gastrointestinal mucosal injury. The combination raises the likelihood of serious bleeding.
How serious is the interaction between Nabumetone and Phenindione?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the NSAID when possible and use paracetamol instead. If unavoidable, monitor INR closely and consider gastroprotection.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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