Drug interactions
Nabumetone + Phenoxybenzamine
Severity: Minor
Nabumetone and Phenoxybenzamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenoxybenzamine is an alpha-blocker used for pheochromocytoma and bladder dysfunction. NSAIDs may modestly reduce its blood pressure lowering effect through fluid retention and prostaglandin inhibition.
What this interaction means in plain words
Nabumetone and Phenoxybenzamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
NSAID-mediated prostaglandin inhibition may partly counter vasodilation; evidence is theoretical.
What to do
Monitor blood pressure if nabumetone is used regularly with phenoxybenzamine. Adjust the phenoxybenzamine dose if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Nabumetone with Phenoxybenzamine?
MediHelp rates the interaction as minor. Nabumetone and Phenoxybenzamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenoxybenzamine is an alpha-blocker used for pheochromocytoma and bladder dysfunction. NSAIDs may modestly reduce its blood pressure lowering effect through fluid retention and prostaglandin inhibition.
How serious is the interaction between Nabumetone and Phenoxybenzamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if nabumetone is used regularly with phenoxybenzamine. Adjust the phenoxybenzamine dose if control worsens.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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