Drug interactions
Nabumetone + Sacubitril / valsartan
Severity: Major
Nabumetone and Sacubitril / valsartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the antihypertensive effect of sacubitril/valsartan and, by constricting the renal afferent arteriole while the drug blocks the efferent arteriole, may cause acute kidney injury and hyperkalemia. The risk is highest in elderly, volume-depleted or renally impaired patients.
What this interaction means in plain words
Nabumetone and Sacubitril / valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
NSAID inhibition of renal prostaglandins reduces glomerular perfusion and sodium excretion, adding to angiotensin receptor blockade and causing potassium retention.
What to do
Avoid the combination in volume-depleted or renally impaired patients. Otherwise monitor blood pressure, serum creatinine and potassium after starting or changing the NSAID.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Nabumetone with Sacubitril / valsartan?
MediHelp rates the interaction as major. Nabumetone and Sacubitril / valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs can reduce the antihypertensive effect of sacubitril/valsartan and, by constricting the renal afferent arteriole while the drug blocks the efferent arteriole, may cause acute kidney injury and hyperkalemia. The risk is highest in elderly, volume-depleted or renally impaired patients.
How serious is the interaction between Nabumetone and Sacubitril / valsartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in volume-depleted or renally impaired patients. Otherwise monitor blood pressure, serum creatinine and potassium after starting or changing the NSAID.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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