Drug interactions
Nabumetone + Salsalate
Severity: Moderate
Nabumetone and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a non-acetylated salicylate that is hydrolyzed to salicylic acid, so combining it with nabumetone duplicates NSAID therapy. This adds to the risk of gastrointestinal toxicity, renal impairment and potassium retention without proven added benefit.
What this interaction means in plain words
Nabumetone and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of prostaglandin synthesis affecting gastrointestinal, renal and platelet function.
What to do
Avoid using both together and choose one agent at the lowest effective dose. If the combination is unavoidable, monitor renal function, potassium and signs of gastrointestinal bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Nabumetone with Salsalate?
MediHelp rates the interaction as moderate. Nabumetone and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is a non-acetylated salicylate that is hydrolyzed to salicylic acid, so combining it with nabumetone duplicates NSAID therapy. This adds to the risk of gastrointestinal toxicity, renal impairment and potassium retention without proven added benefit.
How serious is the interaction between Nabumetone and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using both together and choose one agent at the lowest effective dose. If the combination is unavoidable, monitor renal function, potassium and signs of gastrointestinal bleeding.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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