Drug interactions
Nabumetone + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Severity: Moderate
Nabumetone and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel preparations cause fluid loss and electrolyte shifts, and in volume-depleted patients NSAIDs raise the risk of acute kidney injury. NSAIDs may also contribute to water retention and hyponatremia.
What this interaction means in plain words
Nabumetone and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bowel-prep volume depletion and electrolyte loss reduce renal perfusion, while NSAID prostaglandin inhibition impairs renal compensation.
What to do
Ensure adequate hydration and consider withholding nabumetone on the day of bowel preparation, particularly in elderly patients or those with kidney disease. Check electrolytes and renal function if symptoms or risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Nabumetone with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Nabumetone and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bowel preparations cause fluid loss and electrolyte shifts, and in volume-depleted patients NSAIDs raise the risk of acute kidney injury. NSAIDs may also contribute to water retention and hyponatremia.
How serious is the interaction between Nabumetone and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and consider withholding nabumetone on the day of bowel preparation, particularly in elderly patients or those with kidney disease. Check electrolytes and renal function if symptoms or risk factors are present.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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