Drug interactions
Nabumetone + Tenofovir df
Severity: Moderate
Nabumetone and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir is cleared by the kidneys and may cause tubular injury, while NSAIDs reduce renal perfusion. Concurrent use, particularly with high or repeated NSAID doses, has been associated with acute kidney injury.
What this interaction means in plain words
Nabumetone and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity from NSAID prostaglandin inhibition reducing renal blood flow together with tenofovir proximal tubular toxicity.
What to do
Prefer paracetamol or other non-NSAID analgesics. If an NSAID is needed, use the lowest dose for a short period and monitor serum creatinine and phosphate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Nabumetone with Tenofovir df?
MediHelp rates the interaction as moderate. Nabumetone and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir is cleared by the kidneys and may cause tubular injury, while NSAIDs reduce renal perfusion. Concurrent use, particularly with high or repeated NSAID doses, has been associated with acute kidney injury.
How serious is the interaction between Nabumetone and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer paracetamol or other non-NSAID analgesics. If an NSAID is needed, use the lowest dose for a short period and monitor serum creatinine and phosphate.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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