Drug interactions
Nabumetone + Venlafaxine
Severity: Moderate
Nabumetone and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine impairs platelet serotonin uptake, and with an NSAID the risk of bleeding, notably gastrointestinal bleeding, is increased. The effect is greater in older adults and with other bleeding risk factors.
What this interaction means in plain words
Nabumetone and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nabumetone belongs to Musculoskeletal; Venlafaxine belongs to Central Nervous System.
Why it happens
Serotonin reuptake inhibition reduces platelet aggregation, adding to NSAID platelet inhibition and mucosal injury.
What to do
Monitor for bleeding and consider a proton pump inhibitor in patients at risk of gastrointestinal bleeding. Use the lowest effective NSAID dose or an alternative analgesic such as paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Nabumetone with Venlafaxine?
MediHelp rates the interaction as moderate. Nabumetone and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine impairs platelet serotonin uptake, and with an NSAID the risk of bleeding, notably gastrointestinal bleeding, is increased. The effect is greater in older adults and with other bleeding risk factors.
How serious is the interaction between Nabumetone and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and consider a proton pump inhibitor in patients at risk of gastrointestinal bleeding. Use the lowest effective NSAID dose or an alternative analgesic such as paracetamol.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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