Drug interactions
Nabumetone + Willow bark
Severity: Moderate
Nabumetone and Willow bark: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Willow bark contains salicin, which is converted to salicylate, so combining it with an NSAID duplicates salicylate-type therapy. This may add to gastrointestinal irritation, bleeding risk and renal effects.
What this interaction means in plain words
Nabumetone and Willow bark can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects on cyclooxygenase inhibition and platelet function, with possible competition for renal tubular secretion.
What to do
Avoid routine concurrent use of willow bark with nabumetone. If both are taken, watch for GI bleeding symptoms and check renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Nabumetone with Willow bark?
MediHelp rates the interaction as moderate. Nabumetone and Willow bark can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Willow bark contains salicin, which is converted to salicylate, so combining it with an NSAID duplicates salicylate-type therapy. This may add to gastrointestinal irritation, bleeding risk and renal effects.
How serious is the interaction between Nabumetone and Willow bark?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use of willow bark with nabumetone. If both are taken, watch for GI bleeding symptoms and check renal function.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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