Drug interactions
Nadolol + Neostigmine
Severity: Moderate
Nadolol and Neostigmine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Neostigmine increases vagal tone and nadolol blocks sympathetic cardiac drive, so together they may cause pronounced bradycardia or heart block.
What this interaction means in plain words
Nadolol and Neostigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nadolol belongs to Cardiovascular; Neostigmine belongs to Central Nervous System.
Why it happens
Additive negative chronotropic effect from cholinesterase inhibition and beta-adrenergic blockade.
What to do
Monitor heart rate and ECG when neostigmine is given to patients on nadolol, and have an anticholinergic such as atropine or glycopyrrolate available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Other interactions of Neostigmine
Frequently asked questions
Can I take Nadolol with Neostigmine?
MediHelp rates the interaction as moderate. Nadolol and Neostigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Neostigmine increases vagal tone and nadolol blocks sympathetic cardiac drive, so together they may cause pronounced bradycardia or heart block.
How serious is the interaction between Nadolol and Neostigmine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG when neostigmine is given to patients on nadolol, and have an anticholinergic such as atropine or glycopyrrolate available.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.
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