Drug interactions
Nadolol + Nifedipine
Severity: Moderate
Nadolol and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a dihydropyridine calcium channel blocker with a beta blocker often gives additive blood pressure lowering and can be useful. Occasionally it causes excessive hypotension or, in patients with poor ventricular function, heart failure.
What this interaction means in plain words
Nadolol and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nadolol belongs to Cardiovascular; Nifedipine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects on blood pressure, with beta blockade limiting reflex tachycardia and reducing contractility.
What to do
Monitor blood pressure and heart rate during initiation and titration. Use caution in patients with left ventricular dysfunction or conduction disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Nifedipine?
MediHelp rates the interaction as moderate. Nadolol and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a dihydropyridine calcium channel blocker with a beta blocker often gives additive blood pressure lowering and can be useful. Occasionally it causes excessive hypotension or, in patients with poor ventricular function, heart failure.
How serious is the interaction between Nadolol and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during initiation and titration. Use caution in patients with left ventricular dysfunction or conduction disease.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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