Drug interactions
Nadolol + Oxymetazoline
Severity: Moderate
Nadolol and Oxymetazoline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nonselective beta blockade leaves alpha-mediated vasoconstriction unopposed, so an alpha agonist can cause a greater rise in blood pressure with reflex bradycardia. Systemic exposure from intranasal oxymetazoline is low, so effects are usually mild.
What this interaction means in plain words
Nadolol and Oxymetazoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nadolol belongs to Cardiovascular; Oxymetazoline belongs to Respiratory.
Why it happens
Unopposed alpha-1 vasoconstriction when beta-2 mediated vasodilation is blocked.
What to do
Limit oxymetazoline to short courses at labeled doses and monitor blood pressure and heart rate in patients on nonselective beta blockers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymetazoline
- Isocarboxazid + Oxymetazoline Major
- Oxymetazoline + Phenelzine Major
- Oxymetazoline + Tranylcypromine Major
- Amitriptyline + Oxymetazoline Moderate
- Amoxapine + Oxymetazoline Moderate
- Clomipramine + Oxymetazoline Moderate
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Oxymetazoline?
MediHelp rates the interaction as moderate. Nadolol and Oxymetazoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nonselective beta blockade leaves alpha-mediated vasoconstriction unopposed, so an alpha agonist can cause a greater rise in blood pressure with reflex bradycardia. Systemic exposure from intranasal oxymetazoline is low, so effects are usually mild.
How serious is the interaction between Nadolol and Oxymetazoline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit oxymetazoline to short courses at labeled doses and monitor blood pressure and heart rate in patients on nonselective beta blockers.
What other medicines interact with Oxymetazoline?
MediHelp also lists interactions of Oxymetazoline with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Oxymetazoline page.
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