Drug interactions
Nadolol + Primidone
Severity: Minor
Nadolol and Primidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is metabolized to phenobarbital, an enzyme inducer that can reduce beta-blocker levels. Because nadolol is mostly renally cleared, any effect is likely small.
What this interaction means in plain words
Nadolol and Primidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nadolol belongs to Cardiovascular; Primidone belongs to Central Nervous System.
Why it happens
Hepatic enzyme induction by primidone and its metabolite phenobarbital, with limited relevance to nadolol.
What to do
Monitor heart rate and blood pressure when primidone is started or stopped, and adjust nadolol only if response changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Nadolol with Primidone?
MediHelp rates the interaction as minor. Nadolol and Primidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Primidone is metabolized to phenobarbital, an enzyme inducer that can reduce beta-blocker levels. Because nadolol is mostly renally cleared, any effect is likely small.
How serious is the interaction between Nadolol and Primidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when primidone is started or stopped, and adjust nadolol only if response changes.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.
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