Drug interactions
Nadolol + Salmeterol
Severity: Major
Nadolol and Salmeterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol is a nonselective beta-blocker that blocks beta-2 receptors and directly opposes salmeterol's bronchodilation. It may cause severe bronchospasm in patients with asthma or COPD and reduce the benefit of salmeterol.
What this interaction means in plain words
Nadolol and Salmeterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nadolol belongs to Cardiovascular; Salmeterol belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors by a nonselective beta-blocker.
What to do
Avoid nonselective beta-blockers in patients with asthma or COPD who need salmeterol and choose an alternative drug class, or a cardioselective agent with monitoring if a beta-blocker is essential.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Salmeterol?
MediHelp rates the interaction as major. Nadolol and Salmeterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nadolol is a nonselective beta-blocker that blocks beta-2 receptors and directly opposes salmeterol's bronchodilation. It may cause severe bronchospasm in patients with asthma or COPD and reduce the benefit of salmeterol.
How serious is the interaction between Nadolol and Salmeterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid nonselective beta-blockers in patients with asthma or COPD who need salmeterol and choose an alternative drug class, or a cardioselective agent with monitoring if a beta-blocker is essential.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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