Drug interactions
Nadolol + Sotorasib
Severity: Minor
Nadolol and Sotorasib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a P-gp inducer or modulator that may lower exposure to P-gp substrates like nadolol, potentially reducing beta-blocker effect. The expected change is modest.
What this interaction means in plain words
Nadolol and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nadolol belongs to Cardiovascular; Sotorasib belongs to Oncology.
Why it happens
Sotorasib alters P-glycoprotein transport, potentially reducing nadolol absorption.
What to do
Monitor heart rate and blood pressure when starting or stopping sotorasib. Increase nadolol dose if control is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Nadolol with Sotorasib?
MediHelp rates the interaction as minor. Nadolol and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sotorasib is a P-gp inducer or modulator that may lower exposure to P-gp substrates like nadolol, potentially reducing beta-blocker effect. The expected change is modest.
How serious is the interaction between Nadolol and Sotorasib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or stopping sotorasib. Increase nadolol dose if control is inadequate.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.
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