Drug interactions
Nadolol + Triamterene
Severity: Moderate
Nadolol and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol can slightly raise serum potassium by reducing cellular uptake. Together with triamterene, which retains potassium, hyperkalemia becomes more likely, especially with reduced renal function.
What this interaction means in plain words
Nadolol and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nadolol belongs to Cardiovascular; Triamterene belongs to Cardiovascular.
Why it happens
Triamterene reduces renal potassium excretion while nonselective beta-blockade impairs beta-2 mediated cellular potassium uptake.
What to do
Check serum potassium and creatinine at baseline and periodically during combined use. Lower or stop triamterene if hyperkalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Triamterene?
MediHelp rates the interaction as moderate. Nadolol and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nadolol can slightly raise serum potassium by reducing cellular uptake. Together with triamterene, which retains potassium, hyperkalemia becomes more likely, especially with reduced renal function.
How serious is the interaction between Nadolol and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and creatinine at baseline and periodically during combined use. Lower or stop triamterene if hyperkalemia develops.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
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