Drug interactions
Nadolol + Valsartan
Severity: Moderate
Nadolol and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, so combined use can cause additive hypotension and bradycardia-related symptoms. Beta-blockers can also modestly raise potassium, which adds to the hyperkalemia tendency of valsartan.
What this interaction means in plain words
Nadolol and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nadolol belongs to Cardiovascular; Valsartan belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects, with beta-blocker impairment of cellular potassium uptake and angiotensin receptor blockade reducing aldosterone effect.
What to do
Monitor blood pressure, heart rate, and serum potassium, especially in renal impairment or diabetes; this combination is commonly used intentionally with titration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Valsartan?
MediHelp rates the interaction as moderate. Nadolol and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, so combined use can cause additive hypotension and bradycardia-related symptoms. Beta-blockers can also modestly raise potassium, which adds to the hyperkalemia tendency of valsartan.
How serious is the interaction between Nadolol and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate, and serum potassium, especially in renal impairment or diabetes; this combination is commonly used intentionally with titration.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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