Drug interactions
Nafcillin + Ribociclib
Severity: Moderate
Nafcillin and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is a CYP3A4 inducer and may lower ribociclib concentrations, possibly reducing its antitumor effect.
What this interaction means in plain words
Nafcillin and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 by nafcillin increases ribociclib clearance.
What to do
Use an alternative antibiotic where suitable; if nafcillin is required, keep the course short and monitor for loss of efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Nafcillin with Ribociclib?
MediHelp rates the interaction as moderate. Nafcillin and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin is a CYP3A4 inducer and may lower ribociclib concentrations, possibly reducing its antitumor effect.
How serious is the interaction between Nafcillin and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic where suitable; if nafcillin is required, keep the course short and monitor for loss of efficacy.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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