Drug interactions
Nafcillin + Rimegepant
Severity: Moderate
Nafcillin and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin induces CYP3A4 and may lower rimegepant concentrations, potentially reducing its effectiveness.
What this interaction means in plain words
Nafcillin and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 metabolism of rimegepant.
What to do
Avoid combining where possible; if used, monitor for reduced migraine relief and consider an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rimegepant
Frequently asked questions
Can I take Nafcillin with Rimegepant?
MediHelp rates the interaction as moderate. Nafcillin and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin induces CYP3A4 and may lower rimegepant concentrations, potentially reducing its effectiveness.
How serious is the interaction between Nafcillin and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if used, monitor for reduced migraine relief and consider an alternative.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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